![]() While freeze-drying provides superior drying capacity, if time is of the essence, you may consider a vacuum concentrator or evaporator for your application.įinally, if you are shopping for a freeze-drying system, remember to budget for a rotary vane vacuum pump with vacuum deep enough to pull down to 2 x 103 mBar, as well as any glassware or adapters that may be required.įor additional resounces on freeze dryers, including useful articles and a list of manufacturers, visit www.labmanager. Additionally, thick samples require moisture to pass through the layer of dried material, increasing the chance that the sample will thaw and “collapse.” Depending on your sample, freeze-drying can be a lengthy process lasting from hours to weeks. In general, samples with a large surface area will freeze-dry faster than those that are thick or dense. The time required to freeze-dry a sample is dependent on a number of factors, including sample volume, thickness, and surface area the eutectic point and solute concentration of the sample and the temperature of the collector and the maximum vacuum obtained. The most common question concerning freeze-drying is likely, “How long will it take?” The answer, however, is not so direct. Labconco’s FreeZone systems, for example, are able to achieve collector temperatures as low as -105☌, making lyophilization of dilute methanol, ethanol, and acetonitrile possible. In response to this demand, some manufacturers are offering ultra-low temperature freeze-dry systems. However, methanol has a much lower freezing point of -97.6☌, making lyophilization difficult even when it is diluted. Many labs are looking at methanol as an alternative to acetonitrile, due to its general availability and affordability. Cascade systems have dual condensers that can reach -84☌ and would be a suitable choice for these samples. In the case of HPLC samples where the freezing point of acetonitrile is much lower (approximately -42☌), however, you will require a cascade-type collector. Choose a system that is too small and you will overload your collector if your system doesn’t reach the correct temperature or has insufficient vacuum, you will risk sample melt back.įor many biological samples, including urea, blood plasma, serum, and vaccinia, a standard freeze-drying system with a refrigeration system that reaches -50☌ will be sufficient. Choosing a freeze dryer that meets the demands of your application can be a daunting task and requires careful consideration of the samples to be prepared. Knowing your sampleĬontrolling the freeze-drying process is dependent on two factors: the presence of a deep vacuum and a temperature differential of 15 to 20 degrees between the sample’s eutectic temperature (freezing point) and the temperature of the collector. Having an intimate understanding of the physical and chemical properties of the samples you are working with is essential to selecting a process and equipment best suited to your needs. Although the process may seem straightforward, freeze-drying can often be problematic. The process of freeze-drying relies on the balance of only three controllable variables: temperature, pressure, and time. FreeZone.While the immediate benefit of freeze drying is obvious-the ability to store samples at ambient temperatures-freeze-drying also may afford long-term savings by eliminating the need for costly cold storage. Request a quote from our freeze dryer experts today. Freeze dryers designed to deliver consistent, high-quality results to make even the most challenging samples easy. Labconco is the industry leading manufacturer of freeze dryers, freeze drying supplies and equipment. PTFE-coated collectors available for corrosion resistance. ![]() CIN software may be integrated into the lyophilizer control system or may be executed via a separate control system, and the output CIN parameters may be evaluated either as part of the lyophilizer batch record or separately using a validated system output when. -50☌, -84☌, and -105☌ temperature options for a wide range of sample types Having characterized the freeze dryer and the manufacturing environment.Ice collection capacities ranging from 2.5 to 18 liters Benchtop and mobile console models available.End-Zone ™ alert system to indicate when samples have reached dryness.Lyo-Works ™OS for on-board control and display of process parameters including collector temperature and vacuum level, recipe programming, data collection and storage, and more.Large, intuitive touchscreen display for easy operation Our laboratory freeze dryers offer these key features By working together with our clients, we configure tailor-made. FreeZone Freeze Dryers are designed to handle the lyophilization needs of research and pilot plant laboratories. The LYOVAC production freeze dryer is the ultimate pharmaceutical lyophilizer from GEA.
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